DRUG GUIDELINE

Alteplase - Restoring Patency to Central Venous Access Devices (CVADs)

SCOPE (Area): Emergency, ICU, Dialysis Unit, General Wards, (Exclude: Paediatrics Seek Advice), Chemotherapy Day Unit, Coronory Care Unit, Grampians Health At Home (ballarat)

SCOPE (Staff): Medical, Nursing, Clinical Staff, Pharmacy

Printed versions of this document SHOULD NOT be considered up to date / current

Preamble

See Appendix 1 for details of this drug guideline

References

	Alfred Health (2021, March). Alteplase Instillation for Management of Blocked Haemodialysis Catheters. Personal communication received June 16th 2022.
	Alfred Health (Version 3). Intraluminal Alteplase for Management of Blocked Peripherally Inserted Central Catheter (PICC). Personal communication received June 16th 2022.
	Barwon Health (2019, February). CVAD Insertion and Management for Adults and Paediatrics. Personal communication received June 17th 2022.
	Cancer Institute NSW. (2022 October). eviQ – Patency management algorithm for central venous access devices, Clinical procedure – restoring patency to a central venous access device – partial and complete occlusion. Retrieved October 18, 2022.
	Datapharm Ltd, (2022, July). Summary of Product Characteristics: Actilyse Cathflo 2mg powder for solution for injection and infusion. Retrieved October 18, 2022.
	Melbourne Health (2021, January). Administration of Alteplase for Thrombolysis for Vascular Catheters and Peritoneal Dialysis Catheters Version 5.1. Retrieved July 6th 2022 from CPG0065 Haemodialysis Perm Catheter Procedures reference section.
	Peter MacCallum Cancer Centre (2022, February). Use of alteplase to restore patency in occluded Central Venous Access Devices (CVADs). Personal communication received March 11th 2016.
	Roche Canada. (2022, December). Cathflo® Product Monograph. Retrieved December 13, 2022.
	Rossi, S. (2022, July). Australian Medicines Handbook. Retrieved July 7, 2022.
	The Society of Hospital Pharmacists of Australia. 2022. Australian Injectable Drugs Handbook (8th ed.). Collingwood: The Society of Hospital Pharmacists of Australia. Retrieved July 7, 2022.
	Therapeutic Goods Administration. (2023, January). Special Access Scheme and Authorised Prescriber online system. Retrieved January 31, 2023
	UBM Medica. (2022, July). MIMS Online, Actilyse® product information. Retrieved July 7, 2022.

Appendix

	Appendix 1 - Alteplase - Restoring Patency to CVADs
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Reg Authority: Medication Safety & Governance Committee (MSGC)	Date Effective: 06/02/2023
Review Responsibility: Pharmacist - Rotational	Date for Review: 06/02/2026

Alteplase - Restoring Patency to Central Venous Access Devices (CVADs) - DRG0055 - Version: 2 - (Generated On: 16-05-2025 05:53)

Preamble

Related Documents

References

Appendix